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COTI selected for Canadian life sciences partnering mission

November 10, 2015

Higher tangle density adversely affected all forms of cognition at all trajectory points. Both Lewy bodies and stroke approximately doubled the rate of gradual memory decline, and almost no gradual decline was seen in the absence of lesions.

"Our study finds that Alzheimer's disease and related dementias are the root cause of virtually all loss of cognition and memory in old age. They aren't the only contributing factors; other factors affect how vulnerable we are to the pathology and to its effects. But the pathology does appear to be the main force that is driving cognitive decline in old age," said Wilson.

According to Wilson, recognizing that the earliest changes in memory are related to Alzheimer's pathology can lead to early diagnosis and will be critical information if a treatment is developed that can alter the pathologic course of the disease.

Source: Rush University Medical Center