NYC Healthcare News



EVP-6124 receptor acts as co-agonist with ACh to enhance cognition

December 16, 2015

"Low doses of EVP-6124 could enhance current cholinergic treatments and when combined with available agents could provide a pro-cognitive effect for as long as acetylcholine is present in the brain," said Dr. Jeff Cummings, director of the Cleveland Clinic Lou Ruvo Center for Brain Health (Las Vegas, Nevada and Cleveland, Ohio).  "EnVivo's experimental results suggest that pro-cognitive drugs could be taken in earlier stages of Alzheimer's disease and that EVP-6124 could continue to boost the pro-cognitive effect of cholinesterase inhibitors throughout the disease course.  The effectiveness of reduced doses of cholinesterase inhibitors when given with EVP-6124 in experimental models suggests that EVP-6124 might allow use of lower doses with fewer side effects in humans."

The results of EnVivo's ongoing Phase IIb trial, expected in the second half of 2011, will hopefully further corroborate EnVivo's most recent findings.

SOURCE EnVivo Pharmaceuticals