NYC Healthcare News

Potential therapy to enhance memory and prevent loss of long-term memory

January 31, 2016

In collaboration with Robert Blitzer, PhD, Associate Professor of Pharmacology and Systems Therapeutics and Psychiatry at Mount Sinai, the research team also evaluated the impact of IGF-II at the cellular level. They found that IGF-II had an impact on long-term potentiation (LTP). LTP is a type of synaptic plasticity, or the change in strength of the points of contact between nerve cells, that is believed to be critical for long-term memory formation. Dr. Blitzer and his team found that IGF-II promoted stable LTP, strengthening signal transmission between nerve cells and maintaining it for a longer period of time.

"This study is the first step to understanding the benefits of IGF-II," said Dr. Alberini. "We have identified some of the mechanisms associated with this effect and look forward to further studying them and exploring the clinical relevance of IGF-II."

SOURCE Mount Sinai Medical Center